Covid-19 (SARS-CoV-2) is a new coronavirus.Since the declaration of a global pandemic, a lot has been learnt about its spread, disease pattern, diagnosis and management.The lungs remain the prime organs to incur serious insult and when lung complications embark, significant morbidity and mortality is jean louis sanchet observed.Predominantly, patch
It has been hypothesized that complex englacial structures identified within the East Antarctic and Greenland ice sheets are generated by (i) water freezing to the ice sheet base and evolving under ice flow, (ii) deformation of ice of varying rheology, or (iii) entrainment of basal material.Using ice-penetrating radar, we identify a widespread comp
Cancer cells show a formidable capacity to survive under stringent conditions, to elude mechanisms of control, such as apoptosis, and to resist therapy.Cancer cells reprogram their metabolism to support uncontrolled proliferation and metastatic progression.Phenotypic and functional heterogeneity are hallmarks of cancer cells, which endow them with
Abstract Animal studies have demonstrated the ability of pancreatic acinar cells to transform into pancreatic ductal adenocarcinoma (PDAC).However, the tumorigenic potential of human pancreatic acinar cells remains under debate.To address this gap in knowledge, we expand sorted human acinar cells as 3D organoids and genetically modify them through